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Today’s healthcare marketplace is more complex than ever. Labs today are faced with increasing regulatory and quality demands coupled with a shortage of skilled labor. QuidelOrtho is committed to helping labs meet these challenges head-on. Join us every month as we discuss the complex questions labs are facing every day.
Episodes
Wednesday Nov 30, 2022
Diagnostic Testing for Type I/II Diabetes and Associated Complications
Wednesday Nov 30, 2022
Wednesday Nov 30, 2022
World Diabetes Day takes place each year in the month of November, created to raise awareness about the disease. Diabetes is a global health threat diabetes with the number of people living with diabetes continuing to rise. Diagnostic testing is one of the major tools to help prevent and manage the disease.
About our Speaker:
Dr. Amy L. Pyle earned her Ph.D. in Molecular Pathology from Vanderbilt University. Following graduate school, Dr. Pyle completed a post-doctoral fellowship in Clinical Chemistry at Vanderbilt University. Dr. Pyle took a position as Assistant Director of Core Laboratories at Nationwide Children's Hospital in 2011. Throughout her training, Dr. Pyle published multiple abstracts, papers, and book chapters, and has received numerous awards for her contributions to the scientific community.
Thursday Oct 27, 2022
Resolving Antibodies to High-Prevalence Antigens
Thursday Oct 27, 2022
Thursday Oct 27, 2022
High-prevalence antigens occur in greater than 99% of the population. Antibodies to high-prevalence antigens are rare and may be difficult to identify due to the lack of antigen-negative panel cells for these antigens. Examples of antibodies to high-prevalence antigens are: anti-k, anti-Kpb, anti-Jsb, and anti-Lub among many others
There is a need to proper identify these antibodies before transfusion to differentiate clinically significant antibodies, that could cause hemolytic transfusion reactions or hemolytic disease of the fetus and newborn from those with little or no clinical relevance. Their specific identification is often difficult, labor-intensive, and time-consuming and it may be difficult to find antigen-negative compatible blood for the patient in need of a transfusion
Learn in this episode clues to recognize if an antibody to a high-prevalence antigen is present and how to apply practices for their identification in the lab and additional recommendations for patient management.
About Our Speaker:
Shane Grimsley, DipRCPath; holds a diplomate in Pathology from the Royal College of Pathologists, UK and has been working at the International Blood Group Reference Laboratory, NHSBT in the UK since 2009, as laboratory manager from 2015 and Senior Clinical Scientist since 2020. Since 2017, Shane has been the lead scientific advisor to the UK NEQAS Red Cell Genotyping scientific advisory group, compiling complex reports to help educate the users. He has been an active member of the editorial board for Immunohematology as well as a reviewer for Vox Sanguinis and Transfusion Medicine since 2019.
Shane is the winner of the 2020 Race and Sanger award from the British Blood Transfusion Society for outstanding contribution to the field of Transfusion, primarily for his work developing a genotyping platform for accurate prediction of variant phenotypes in patients with Sickle Cell Disorder. He also is a winner of the 2010 Margaret Kenwright Young Scientist of the year from the British Blood Transfusion Society, for his work resolving complex compound heterozygous allele combinations and the identifying the associated antibody specificities.
Shane is an international scientific speaker and a workshop instructor for immunohematology topics in conference programs, such as ISBT. He also has been involved in the identification of new blood group systems, new antigens and novel alleles. Shane is helping lead a team of skilled and passionate scientists to resolve the world’s most complex immunohematology cases, contributing to ground-breaking projects that have improved the standards of care for patients.
Wednesday Sep 28, 2022
Understanding sepsis, its detection and treatment strategies
Wednesday Sep 28, 2022
Wednesday Sep 28, 2022
Sepsis occurs when the body’s immune system responds to an infection and injures its own tissues and organs. It is a medical emergency, requiring early detection and treatment as it can lead to septic shock, multi-organ failure, and death. One in five deaths worldwide is associated with sepsis and 40% of cases are in children under five years of age. Sepsis is the number one cause of death in hospitals, the number one cause of hospital readmissions, and the number one healthcare cost.
Laboratory testing is essential in helping prevent, detect, and treat sepsis to minimize injury to the body and the risk of death.
About Our Speaker:
Dr. Lui Forni is a Professor and Consultant Nephrologist and Intensivist at Royal Surrey County Hospital NHS Foundation Trust in Guildford, England. Professor Forni earned a PhD in physical chemistry and subsequently studied medicine, specializing in nephrology and intensive care medicine. His research interests include pre-operative assessment of high-risk surgical candidates, renal replacement therapy, diagnosis, pathophysiology and treatment of acute kidney injury, and predictive modeling in acute medical admissions. He lectures both nationally and internationally and has published widely. He served as the Past Research Chair and is the Current Secretary of the European Society of Intensive Care Medicine.
Wednesday Aug 17, 2022
Key Learnings on Rare Blood Programs
Wednesday Aug 17, 2022
Wednesday Aug 17, 2022
A rare donor program is a collaborative effort of many blood centers and/or hospitals to combine their rare donor resources to supply what they have to patients in need. These centers work to identify rare donors by screening methods and inclusion in database systems.
Learn in this episode what resources are available to the medical community to ensure availability for patients in need of blood and why it is critical to national and international collaboration through joint programs.
About our Speaker:
Sandra Nance has provided leadership to the American Rare Donor Program, American Red Cross Histocompatibility and Immunogenetics laboratories, the National Reference Laboratories for Blood Group Serology, Molecular Testing, Neutrophil and Specialized Testing. She engineered the nationalized American Red Cross SBB Program. She is now a volunteer for the American Red Cross and Emeritus Adjunct Assistant Professor at the University of Pennsylvania in the Department of Pathology and Laboratory Medicine. She earned her Master in Pathology from the University of Maryland and her SBB from The Johns Hopkins Medical Institutions.
Ms. Nance held leadership positions in the AABB, ASCP, ICII, and ISBT. She chaired the ISBT Working Party on Rare Donors and conceptualized the ISBT Working Party on Immunohematology, and as the past Chair, managed the Case Studies.
She has been inducted into the ASCP and the National Blood Foundation Halls of Fame and has received the AABB’s Sally Frank, John Elliott and President’s Awards, AIMS John Moulds, CBBS Suzanne Ledin, MAABB Kay Beattie, New York Supervisors Ron Dubin, and UTMB Jean Stubbins awards. She is the past Editor in Chief of Immunohematology Journal of Blood Group Serology and Molecular Genetics, is a member of Transfusion’s Editorial Board and reviews for several journals. She developed the polyethylene glycol method for serologic testing and the monocyte monolayer assay (MMA) to predict in vivo survival of transfused incompatible red cells. She initiated the International MMA Training classes so other countries can implement the MMA to assist with patients requiring rare blood. Ms. Nance has been invited to present over 250 lectures and has been a frequent contributor to the scientific literature.
Monday Jun 13, 2022
Monday Jun 13, 2022
In Sickle Cell Disease (SCD) patients, one of the most critical treatments is a blood transfusion. A blood transfusion is used to provide normal red blood cells to the patient’s body. Red blood cell transfusions help lessen anemia and reduce the blood’s viscosity, allowing it to flow more freely, ease disease symptoms and prevent complications. Alloimmunization is common in patients with SCD and may complicate transfusion therapy. For many patients, a close blood type match is essential and is found in donors of the same race or similar ethnicity.
In this episode, learn why patient phenotyping and prophylactic matching to reduce alloimmunization is recommended for SCD patients and why donor source for blood donations of the same race or similar ethnicity is critical.
About the Speaker:
Dr. Stella T. Chou is Chief of the Division of Transfusion Medicine, board-certified in Blood Banking and Transfusion Medicine, and an attending physician in the Division of Hematology at Children's Hospital of Philadelphia. Dr. Chou earned her medical degree from New York Medical College in Valhalla, NY. She specializes in caring for children with SCD, those who make antibodies against red blood cell transfusions (alloimmunization), and those requiring apheresis. Her research interests are focused on improving red blood cell matching for patients through the use of innovative tools.
Her work has demonstrated that inheritance of variant blood group antigens in patients with SCD contributes to their high rate of red blood cell antibody formation. Her ongoing work focuses on the genetic matching of red blood cells and creating customized induced pluripotent stem cells (iPSCs) with rare blood group antigen combinations as renewable sources of red blood cell reagents to improve antibody identification and donor red blood cell matching. For her innovative research, she is a recipient of the National Blood Foundation Hall of Fame award. Dr. Chou is a worldwide recognized author and speaker with over 100 publications and lectures. In addition to her clinical work, Dr. Chou serves as an Associate Professor of Pediatrics at the Perelman School of Medicine, University of Pennsylvania.
Wednesday Jun 08, 2022
The importance of extended antigen typing in Transfusion Medicine
Wednesday Jun 08, 2022
Wednesday Jun 08, 2022
Review the role of extended antigen typing or phenotyping in Transfusion Medicine. How this practice plays a significant role in the transfusion of sickle cell, thalassemia, and myelodysplastic syndrome patients as well as other chronically transfused patients, preventing the development of foreign antibodies which may avoid the challenges that come later with complex antibody problems and brings the additional benefit of allowing finding compatible blood for patients in need of a transfusion. In this podcast edition, we will explore those key points and more.
About our Speaker: Tony S. Casina, MT(ASCP)SBB has worked in the blood banking industry for over 40 years with much of it in the commercial blood bank reagent manufacturers sector with hospital experience as a medical technologist and blood bank manager. Tony has provided technical support to laboratories throughout the world utilizing Ortho’s reagents and immunohematology test systems. He has tested some of the most challenging antibody problems as part of his reference laboratory experience. Tony has been an active participant in the AABB serving on committees and currently on the AABB Board of Directors. He has contributed as a presenter to AABB and regional blood bank meetings educational programs. He was extensively involved in the development of the ORTHO VISION® Analyzer Platform.
Tuesday May 31, 2022
The Role of the Lab in Diagnosing and Monitoring Hepatitis C Virus Infection
Tuesday May 31, 2022
Tuesday May 31, 2022
The World Health Organization estimated that during 2019, 58 million people worldwide were living with the Hepatitis C virus (HCV) which causes inflammation of the liver. All types of hepatitis can be controlled or prevented. There is a cure for Hepatitis C; however, HCV infection is often undiagnosed because it remains asymptomatic until symptoms appear that are related to serious liver damage, a complication of the infection.
ABOUT THE SPEAKER
Dr. Bijal Parikh is the Medical Director of the Molecular Diagnostics Laboratory and Assistant Professor of Pathology & Immunology at Washington University in St. Louis, Missouri.
He is the author of numerous publications with his clinical research centered on aspects of laboratory testing involving viral, immunologic, and molecular diagnostics, with a specific focus on the implementation of next-generation sequencing approaches. Recently, Dr. Parikh authored an article published in the Clinical Microbiology Newsletter titled Laboratory Strategies for Diagnosis and Monitoring of Hepatitis C Virus Infection.
Wednesday Apr 20, 2022
Laboratory Investigations for Maternal Health Testing
Wednesday Apr 20, 2022
Wednesday Apr 20, 2022
Maternal health refers to the health of the women during pregnancy, childbirth, and the postnatal period. Each stage should be a positive experience, ensuring women and their babies reach their full potential for health and well-being. Prenatal care includes screening and diagnostic tests and they can provide valuable information about the baby's health. Understand the risks and benefits.
The obstetrician in partnership with the laboratory has tools that can contribute to maternal health, such as:
• Prenatal screening tests which can identify potential genetic disorders and diagnostic tests, and,
• Diagnostic test, which is the only way to be sure of a diagnosis.
Learn in this episode what are the strategies to minimize the risk of alloimmunization in the maternal population and what are the recommendations for antenatal and post-delivery care testing.
About Our Speaker:
Professor Robert Flower is a national leader in R&D at the Australian Red Cross Lifeblood. He has been teaching and supervising hospital and university blood banks for over 30 years. He has published over 400 publications with over 4000 citations and has helped over 50 students complete post-graduate research. In 2018, Dr. Flower was granted the Vice Chancellor’s Award for Excellence at Queensland University of Technology. The following year, he was awarded the Peter Schiff Award from the Australia and New Zealand Society for Blood Transfusion. Dr. Flower’s current interests include translating genetics to routine investigations, molecular modeling of the structures defining blood groups, and evidence-based modeling of the risk of transfusion-transmission for various agents.
Monday Mar 28, 2022
Diagnosing Chronic Kidney Disease
Monday Mar 28, 2022
Monday Mar 28, 2022
It is estimated that between 8 and 10% of the global adult population has some form of kidney damage. Early detection of kidney damage is critical. If left undetected, chronic kidney disease can lead to kidney failure which means regular dialysis treatment or a kidney transplant is necessary for survival.
In this podcast episode, we will discuss who is at risk for chronic kidney disease, screening strategies, and ways to classify the level of impairment. In addition, we’ll discuss a unifying approach for estimating glomerular filtration rate (eGFR) in the United States with the recommendations published by a task force established by the National Kidney Foundation and the American Society of Nephrology.
About our Speaker:
Dr. Claudio Suárez graduated from the University of Chile with a degree in Medicine and a specialty in Laboratory Medicine. His experience in the clinical laboratory at the University Hospital motivated him to get a Master’s degree in Industrial Engineering and Systems at the University for Development in Chile. He is also Lean Certified by the University of Michigan.
Dr. Suarez had leadership roles in different types of laboratories, public and private, being responsible for clinical chemistry and post-analytical departments. In the second half of his career, Dr. Suarez extended his experience to the IVD industry, leading regional consultancy teams across Latin America for the design and implementation of lab solutions. He has been a regular speaker in different areas of laboratory medicine. Currently, Dr. Suarez is the Regional Medical Director for Latin America and a member of the Global Medical & Scientific Affairs team at Ortho Clinical Diagnostics.
Monday Feb 28, 2022
Heart Failure and the role of NT-proBNP
Monday Feb 28, 2022
Monday Feb 28, 2022
Heart Failure (HF) is a common disease that affects an estimated global population of over 40 million. It is the most frequent cause of hospitalizations in patients over the age of 65, placing a considerable financial and social burden on patients, healthcare providers, and care providers. Accurate clinical assessment of HF and cost-effective management strategies are critical in improving patient outcomes and reducing the socioeconomic burden of this disease.
In this podcast episode, we will have a conversation between Dr. Christopher deFilippi, a cardiologist at the Inova Heart and Vascular Institute, and Dr. Ivan Salgo to learn more about heart failure, how it is diagnosed, and the value of using the in-vitro diagnostic test NT-proBNP.
About our Speaker:
Dr. Christopher deFilippi is a distinguished cardiologist who currently works at the Inova Heart and Vascular Institute (IHVI) in Fairfax, Virginia as the Vice-Chair of Academic Affairs.
In his oversight of clinical research, he has built IHVI to be a national leader in site-based research. He serves on the Editorial boards of Circulation, JACC, and JACC: Heart Failure. He is an Associate Editor for the Journal of Applied Laboratory Medicine. His research is focused on evaluating in-vitro diagnostics and proteomics discovery for diagnosis, prognosis, and therapy guidance across the spectrum of health from detection of preclinical cardiovascular disease to diagnosis and treatment in the critically ill.